| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
2011 German Escherichia coli O104:H4 outbreak: Alignment-free whole-genome phylogeny by feature frequency profiles
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| Autores: |
Man Kit Cheung
Lei Li
Wenyan Nong
Hoi Shan Kwan
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| Data: |
2011-07-27
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| Ano: |
2011
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| Palavras-chave: |
Genetics & Genomics
Microbiology
Bioinformatics
Evolutionary Biology
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| Resumo: |
Accuracy of SNP-based whole-genome phylogeny reconstruction relies heavily on quality of sequence alignment which is particularly hindered by poorly assembled genomes. Alignment-free methods might provide additional insights. Here, we constructed a whole-genome phylogeny of 10 isolates from the current German E. coli outbreak against 30 existing E. coli genomes as well as that of a historical EHEC isolate using the alignment-free feature frequency profile method. Our results revealed a high similarity among E. coli isolates from the current outbreak and the historical EHEC being the most closely related isolate sequenced thus far.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/6109/version/2
oai:nature.com:10.1038/npre.2011.6109.2
http://dx.doi.org/10.1038/npre.2011.6109.2
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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